Clinical features of Chinese patients with Takotsubo syndrome / 中华心血管病杂志

Objective: To analyze the characteristics, diagnosis and treatment status of Takotsubo syndrome (TTS) of Chinese patients. Methods: Complete literature review was performed to summarize Chinese TTS cases between 2007 and 2018. Results: A total of 131 literatures were included including 160 TTS patients (age (58.3±14.7) years). There were 137 female patients (85.6%) in this cohort, the age was (59.6±14.0) years. There were 124 cases (77.5%) of stress-evoking factors, of which 83 cases (66.9%) were self-stress factors. There were 97 cases (60.6%) complained of chest pain and 15 cases (9.4%) with syncope. Forty-eight cases (30.0%) presented with cardiogenic shock. CK-MB and cTnT/I increased in 109 cases (80.1%). There were 124 cases (77.5%) presented with ST segment elevation on electrocardiogram, which were common in lead V2-V5. Echocardiography results were available in 128 cases (80.0%), reduced left ventricular ejection fraction (<50%) was reported in 78 cases (73.6%). Coronary angiography was performed in 133 patients (83.1%), of which 126 patients (94.7%) had normal coronary arteries or single non-significant stenosis. One hundred and thirty-eight patients (87.3%) were apical type. The misdiagnosis rate on admission was 96.9% (155/160), of which 141 cases (88.1%) were misdiagnosed as acute myocardial infarction. Nitroglycerin was used in 36 patients (30.3%). Angiotensin converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist were used in 38 patients (31.9%). β blockers were used in 46 patients (38.7 %). Dopamine was used in 22 cases (18.5%) and norepinephrine was used in 12 cases (10.1%). Intra-aortic balloon counter pulsation was used in 5 cases (3.1%). Cardiopulmonary resuscitation was performed in 9 cases (5.6%). Cardiac function recovery time was 7 (6, 15) days. The average InterTAK diagnosis score was (51.5±18.1) points, and value was>70 points in 2 cases (1.3%). There were 92 patients in the high-risk group, and there were 3 recurrent TTS cases. Five patients died. Conclusions: TTS incidence tends to be young and dominates in female in China. The misdiagnosis rate is extremely high on admission. Most patients are treated with medication.

Síndrome de Tako-Tsubo en perioperatorio: Una variante rara. Reporte de caso / Tako-Tsubo syndrome in perioperative: A rare variant. Case report

Tako-Tsubo syndrome or stress-induced cardiomyopathy has been described as a transient left ventricular apical dyskinesia with chest pain and ST-segment elevation on electrocardiogram in the absence of obstructive lesions in coronary arteriography, most commonly in perimenopausal women. It is a rare pathology, with five reported variations and debated pathophysiological mechanisms. The current most accepted theory is a surge of catecholaminergic discharge, associated with genetic predisposition and an emotional or physical stress factor as trigger. We report a case of a 27-year-old woman with a history of uncontrolled asthma and a brother with early heart disease. She underwent appendectomy under general anesthesia and immediately after extubation, she presented a drop in oxygen saturation, respiratory distress, oppressive chest pain, severe arterial hypotension and acute pulmonary edema, requiring reintubation. ST depression on electrocardiogram, positive troponins, coronary arteriography without obstructive lesions, and mid-ventricular hypokinesia was observed in the complementary cardiac studies. Based in these findings, stress cardiomyopathy was diagnosed. The patient progressed favorably, four months after discharge, the patient remained asymptomatic with no changes in the cardiac studies.

El síndrome de Tako-Tsubo o miocardiopatía por estrés es descrito como una discinesia apical transitoria con cuadro de dolor torácico típico y electrocardiograma con elevación del segmento ST ante ausencia de lesiones en arteriografía coronaria, presentada principalmente en mujeres perimenopáusicas. Se reconoce como una patología poco frecuente, con 5 variaciones reportadas y de la que aún se debaten los mecanismos fisiopatológicos, siendo la descarga catecolaminérgica, asociada a predisposición genética y un factor emocional y/o físico desencadenante, la teoría más aceptada hoy en día. Se presenta el caso de una mujer de 27 años con antecedente de asma no controlada y hermano con enfermedad cardiaca temprana, que es llevada a apendicectomía abierta bajo anestesia general e inmediatamente a la extubación presenta caída de la saturación de oxígeno, dificultad respiratoria, refiere dolor torácico opresivo, hipotensión arterial severa y edema agudo de pulmón, con requerimiento de nueva intubación; electrocardiograma con infradesnivel del ST, troponinas positivas, arteriografía coronaria sin lesiones e hipocinesia medioventricular, con lo que se diagnostica miocardiopatía por estrés. Evolución favorable y egreso, y seguimiento a los 4 meses con exámenes normales.

The Clinical Course of Takotsubo Syndrome Diagnosed According to the InterTAK Criteria

Abstract Background There has been an increase in the number of cases of Takotsubo syndrome (TTS) and of scientific publications on the theme over the last years. However, little is known about the status of this disease in Brazilian hospitals. Objective To assess mortality and major adverse cardiovascular events (MACE) during hospitalization and follow-up of TTS patients seen in a tertiary hospital in Brazil. Methods This was a retrospective, observational study on 48 patients. Clinical data, signs and symptoms, complementary tests, MACE and all-cause mortality were assessed on admission and during follow-up. Kaplan-Meier curves were used for analysis of all-cause mortality and risk for MACE at median follow-up. The 95% confidence interval was also calculated for a significance level of 5%. Results Mean age of patients was 71 years (SD±13 years), and most patients were women (n=41; 85.4%). During hospitalization, four patients (8.3%) died and five (10.4%) developed MACE. At median follow-up of 354.5 days (IQR of 81.5-896.5 days), the risk of all-cause mortality and MACE was 11.1% (95% CI= 1.8-20.3%) and 12.7% (95% CI= 3.3-22.3%), respectively. Conclusion TTS was associated with high morbidity and mortality rates in a tertiary hospital in Brazil, which were comparable to those observed in acute coronary syndrome. Therefore, the severity of TTS should not be underestimated, and new therapeutic strategies are required. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0

Miocardiopatía de y movimiento sistólico anterior de válvula mitral / Myocardiopaty and sistolic anterior movement of mitral valve

Tako tsubo cardiomyopathy associated with left ventricular outflow tract obstruction (LVOT) is a rare cause of persistent perioperative hypotension. One of the causes of this association is the systolic anterior motion (SAM) of the mitral valve. We report a case of a 67-year-old woman who, after undergoing liver segmentectomy because of metastasis, presents post-operative hypotension that is difficult to manage. Upon evaluation with a transthoracic echocardiogram, the diagnostic suspicion of Tako tsubo syndrome associated with LVOT obstruction secondary to SAM was raised. As initial therapy, a volume expander, in association with propanolol and phenylephrine were administred, achieving partial hemodynamic response. Later, she evolved with signs of heart failure and was transferred to the intensive care unit for management. In this unit, non-invasive ventilatory support, diuretic and vasopressor therapy were required, achieving favorable results on the second post-operative day. Echocardiography was essential to make the differential diagnosis against a persistent post-operative hypotension

La cardiomiopatía de Tako tsubo asociada a obstrucción del tracto de salida del ventrículo izquierdo (TSVI) es una causa poco frecuente de hipotensión persistente en el perioperatorio. Uno de los motivos de esta asociación es el movimiento anormal sistólico (SAM) de la válvula mitral. A continuación, presentamos el caso de una mujer de 67 años que, tras ser sometida a segmentectomía hepática por metástasis, presenta cuadro de hipotensión postoperatoria de difícil manejo. Al ser evaluada con ecocardiograma transtorácico se plantea la sospecha diagnóstica de síndrome de Tako tsubo asociado a obstrucción del TSVI secundario a SAM. Como terapia inicial se realizó aporte de volumen, en asociación con propanolol y fenilefrina, logrando parcial respuesta hemodinámica. Posteriormente, evolucionó con signos de insuficiencia cardiaca y fue trasladada a unidad de cuidados intensivos para su manejo. En esta unidad requirió apoyo ventilatorio no invasivo, terapia diurética y vasopresora, logrando resultados favorables al segundo día postoperatorio. La ecocardiografía fue fundamental para realizar el diagnóstico diferencial frente a un cuadro de hipotensión postoperatoria persistente.

Stress induced cardiomyopathy due to a Mexican earthquake / Cardiomiopatía por estrés inducida por el terremoto en México

Abstract Takotsubo Cardiomyopathy mainly occurs in postmenopausal women, with or with- out cardiovascular disease, and is commonly associated with emotional or physical stress. After nearly 27 years of extensive efforts towards a better understanding of this disorder, current knowledge remains limited. Many people suffer post-traumatic stress, and this situation can be associated to stress cardiomyopathy. The case is presented of a female who suffers stress asso- ciated with the earthquake of 19 September 2017 in Mexico City, and arrived in the Emergency Department in cardiogenic shock.

Resumen La miocardiopatía de Takotsubo ocurre principalmente en mujeres posmenopáusicas con o sin enfermedad cardiovascular, y se asocia comúnmente con estrés emocional o físico. Después de casi 27 an˜os de esfuerzos extensos para una mejor comprensión de este trastorno, el conocimiento actual sigue siendo limitado. Muchas personas sufren estrés postraumático y esta situación puede estar asociada a la cardiomiopatía por estrés. Presentamos el caso clínico de una mujer que sufrió estrés relacionado con el pasado terremoto del 19 de septiembre en la Ciudad de México y llegó al servicio de urgencias en choque cardiogénico.

Miocardiopatía inducida por estrés o síndrome de Takotsubo: a propósito de un caso / Cardiomyopathy induced by stress or Takotsubo syndrome: a report of one case

La cardiomiopatía inducida por estrés o Síndrome de Takotsubo se caracteriza por una disfunción aguda del ventrículo izquierdo caracterizado por acinesia o discinesia apical con hipercinesia basal a menudo reversible, en ausencia de obstrucción coronaria en la angiografía. La presentación clínica se asemeja al del Infarto Agudo de Miocardio; con un inicio súbito caracterizado por dolor precordial de tipo isquémico, disnea, palpitaciones, cambios electrocardiográficos, elevación de biomarcadores de necrosis miocárdica y en casos más graves y raros shock cardiogénico; el estrés emocional y físico severo suelen ser desencadenantes. Con el presente caso clínico, revisamos las características clínicas, diagnósticas y terapéuticas de ésta entidad poco frecuente que representa cerca del 1% de todos los pacientes con sospecha de síndrome coronario agudo.

Cardiomyopathy induced by stress or Takotsubo Syndrome is characterized by an acute dysfunction of the left ventricle characterized by apical akinesia or dyskinesia with often reversible basal hyperkinesia, in the absence of coronary occlusion on angiography. The clinical presentation resembles the Acute Myocardial Infarction, with a sudden onset characterized by a chest pain angina type, dyspnea, palpitations, electrocardiographic changes, elevation of cardiac biomarkers and cardiogenic shock in more serious and rare cases; the severe emotional and physical stress tend to be triggers. With this clinical case, we reviewed the clinical, diagnostic and therapeutic features of this rare entity which represents about 1% of all patients with suspected acute coronary syndrome.

Síndrome de Takotsubo e o uso do InterTAK Diagnostic Score no diagnóstico diferencial com a síndrome coronariana aguda: relato de um caso / Takotsubo syndrome and the use of InterTAK Diagnostic Score in the differential diagnosis of acute coronary syndrome: a case report

A Cardiomiopatia de Takotsubo (CT) é uma síndrome cardíaca caracterizada por quadro clínico compatível com síndrome coronariana aguda (SCA), com alterações eletrocardiográficas, aumento de enzimas cardíacas e anormalidades na contratilidade ventricular, geralmente associada a artérias coronárias livres de obstruções ou espasmos significativos à cineangiocoronariografia. Por apresentar curso clínico semelhante ao do infarto agudo do miocárdio, muitas vezes é abordada como tal. O presente trabalho busca, ao relatar um caso clássico de CT, destacar a importância da realização do diagnóstico diferencial entre a CT e a SCA, usando como ferramenta o InterTAK Diagnostic Score. (AU)

Takotsubo cardiomyopathy (TC) is a cardiac syndrome characterized by clinical symptoms compatible with acute coronary syndrome (ACS), including electrocardiographic changes, increased cardiac enzymes, and ventricular wall motion abnormalities, usually associated with absence of obstructive coronary artery disease or significant spasms at coronary angiography. Because its clinical course is similar to that of acute myocardial infarction, TC is often treated as such. The present paper reports a classic case of TC seeking to highlight the importance of performing a differential diagnosis between TC and ACS, using a tool named InterTAK Diagnostic Score. (AU)

Síndrome de tako-tsubo, caracterización clínica y evolución a un año plazo / Tako-tsubo syndrome: analysis of 37 cases

Background: Tako-tsubo Syndrome (TTS) is characterized by transient regional systolic dysfunction of the left ventricle (LV), mimicking myocardial infarction. It accounts for 0.9-1.2% of all acute coronary syndromes (ACS). Aim: To describe the incidence and characteristics of TTS within our population. Material and Methods: All patients diagnosed with ACS and TTS were selected from a clinical registry of all the coronary angiographies done in our hospital. Clinical features during initial presentation, hospital evolution and one year follow-up were analyzed. Results: The first case diagnosed in our hospital occurred in 2001. Since then, 4,433 coronary angiographies were done to patients with ACS until 2014 and 37 corresponded to TTS (0.83% incidence). The mean age of patients was 64 years, 73% were female, and 62% had hypertension. All patients had an identifiable trigger factor, abnormal EKG and elevated troponin. The coronary angiography did not show lesions in 97%. However, all had the characteristic extensive segmental-motility alteration with a mean ejection fraction of 44%. All patients were treated initially as an ACS. Seven patients had complications, namely acute cardiac failure in six and stroke in one. No patient died. At one year of follow-up, 100% showed normal segmental motility and ejection fraction, no patient had a new episode of TTS and all were alive. Conclusions: TTS is rare and the incidence found in this study is slightly lower than that reported elsewhere. TTS mimics ACS and it should be suspected by its clinical, electrocardiographic and enzymatic particularities. Coronary angiography helps to rule out other diagnosis. All patients normalize motility and ventricular function, which is the definitive differential feature respect to ACS.

Miocardiopatía de Tako-Tsubo: una manifestación inusual de feocromocitoma / Takotsubo cardiomyopathy: rare manifestation of pheochromocytoma

Takotsubo cardiomyopathy (MTT) is an acute ventricular dysfunction and reversible in absence of coronary disease. It is a rare presentation of pheochromocytoma and paraganglioma (FPGL). It was described for the first time in 1990 by Sato et al, the physiopathology is not clear yet. It is associated with high levels of catecholamines, vasospasm in the micro vascularization, rupture of atheromatous plaque and myiocarditis. The clinical presentation is similar to an acute myocardial infarction because of that the FPGL must be considered in patients without obstructive coronary lesions. We present a case of a 50 years old women with history of Arterial Hypertension, active smoking and Neurofibromatosis, who is admitted to emergency room with an acute myocardial pain.

Miocardiopatia de Takotsubo pós-parto: relato de caso / Postpartum Takotsubo cardiomyopathy: case report

Ocorrendo habitualmente após um stress físico ou emocional intenso, a miocardiopatia de Takotsubo caracteriza-se por disfunção aguda e transitória do segmento apical do ventrículo esquerdo, mimetizando uma síndrome coronária aguda. Essa é uma síndrome rara, na qual o diagnóstico diferencial assume particular importância. Um elevado nível de suspeição é essencial, pelo que obstetras e o restante da equipe devem estar preparados para diagnosticar e lidar com esse evento inesperado. O tratamento é fundamentalmente de suporte, verificando-se reversão espontânea e completa das alterações num intervalo de dias a semanas. A ocorrência de complicações podem ditar um prognóstico menos benigno. Apresentamos o caso de uma mulher de 39 anos, sem antecedentes relevantes. Submetida à cesariana por suspeita de sofrimento fetal. Terminada a intervenção iniciou quadro de bradicardia e precordialgia, com edema pulmonar. Apresentava alterações de enzimas cardíacas e do electrocardiograma. O ecocardiograma revelou disfunção sistólica do ventrículo esquerdo com hipocinésia de toda a parede anterior. O cateterismo cardíaco excluiu doença coronária obstrutiva.

Takotsubo cardiomyopathy is characterized by acute and transient dysfunction of the apical segment of the left ventricle usually after an intense physical or emotional stress, mimicking an acute coronary syndrome. Because this is a rare syndrome, the differential diagnosis is particularly important and a high level of suspicion is essential. Obstetricians should be aware to diagnose and deal with this unexpected event. Treatment is essentially supportive, with spontaneous and complete reversal of the changes within days or weeks. The occurrence of complications may dictate a less benign prognosis. We report a case of Takotsubo cardiomyopathy in a 39-year-old woman who underwent Cesarean delivery. She presented with bradycardia, chest pain and pulmonary edema immediately after the delivery. Her echocardiography showed and apical ballooning. Cardiac biomarkers and electrocardiogram were altered and echocardiogram showed severe left ventricular dysfunction with hypokinesia of the anterior wall. Coronary angiography excluded obstructive coronary artery disease.

ST-segment elevation during general anesthesia for non-cardiac surgery: a case of takotsubo / Supradesnivelamento do segmento ST durante anestesia geral para cirurgia não cardíaca: um caso de takotsubo

ABSTRACTBACKGROUND AND OBJECTIVES: Takotsubo cardiomyopathy, also known as broken heart syndrome is a stress-induced cardiomyopathy, which can be interpreted as an acute coronary syndrome as it progresses with suggestive electrocardiographic changes. The purpose of this article is to show the importance of proper monitoring during surgery, as well as the presence of an interdisciplinary team to diagnose the syndrome.CASE REPORT: Male patient, 66 years old, with diagnosis of gastric carcinoma, scheduled for diagnostic laparoscopy and possible gastrectomy. In the intraoperative period during laparoscopy, the patient always remained hemodynamically stable, but after conversion to open surgery he presented with ST segment elevation in DII. ECG during surgery was performed and confirmed ST-segment elevation in the inferior wall. The cardiology team was contacted and indicated the emergency catheterization. As the surgery had not yet begun irreversible steps, we opted for the laparotomy closure, and the patient was immediately taken to the hemodynamic room where catheterization was performed showing no coronary injury. The patient was taken to the hospital room where an echocardiogram was performed and showed slight to moderate systolic dysfunction, with akinesia of the mid-apical segments, suggestive of apical ballooning of the left ventricle. Faced with such echocardiographic finding and in the absence of coronary injury, the patient was diagnosed with intraoperative Takotsubo syndrome.CONCLUSION: Because the patient was properly monitored, the early detection of ST-segment elevation was possible. The presence of an interdisciplinary team favored the syndrome early diagnosis, so the patient was again submitted to safely intervention, with the necessary security measures taken for an uneventful new surgical intervention.

RESUMOJUSTIFICATIVA E OBJETIVOS: A cardiomiopatia de takotsubo, também conhecida como síndrome do coração partido, é uma cardiomiopatia induzida por estresse que pode ser interpretada como uma síndrome coronária aguda, pois cursa com alterações eletrocardiográficas sugestivas. O objetivo do presente artigo é mostrar a importância de uma monitoração adequada no intraoperatório, assim como a presença de uma equipe interdisciplinar para o diagnóstico da síndrome.RELATO DE CASO: Doente masculino, 66 anos, com o diagnóstico de carcinoma gástrico, proposto para laparoscopia diagnóstica e possível gastrectomia. No intraoperatório durante a laparoscopia manteve sempre estabilidade hemodinâmica, porém após a conversão para cirurgia aberta apresentou elevação do segmento ST em DII e foi feito um ECG no intraoperatório que confirmou supradesnivelamento do segmento ST em parede inferior. Foi contactada a equipe de cardiologia, que indicou cateterismo de urgência. Como a cirurgia ainda não havia iniciado passos irreversíveis, optou-se pelo encerramento da laparotomia e o doente foi levado imediatamente para a sala de hemodinâmica. Foi feito cateterismo que não evidenciou lesão nas coronárias. O doente foi levado para o internamento, onde foi feito um ecocardiograma que mostrava disfunção sistólica ligeira a moderada, com acinésia dos segmentos médio-apicais, imagem sugestiva de balonamento apical do ventrículo esquerdo. Diante de tal achado ecocardiográfico e na ausência de lesões coronárias, foi diagnosticada síndrome de takotsubo intraoperatória.CONCLUSÃO: Devido ao fato de o doente estar monitorado de uma forma adequada foi possível a detecção precoce do supradesnivelamento do segmento ST. A presença de uma equipe interdisciplinar favoreceu o diagnóstico precoce da síndrome. Dessa forma o doente foi novamente intervencionado de forma segura e foram tomadas as devidas medidas de segurança, para que a nova intervenção cirúrgica transcorresse sem intercorrências.

Cardiomiopatia de Takotsubo após pneumonia: relato de caso / Takotsubo cardiomyopathy after pneumonia: case report

Também chamada de Síndrome do Coração Partido, a Síndrome de Takotsubo é uma doença cardiovascular com quadro clínico semelhante ao infarto agudo do miocárdio, porém, com coronárias normais na cineangiocoronariografia. Normalmente está associado a quadros de estresse emocional ou físico sendo necessário o conhecimento da patologia para diagnóstico e boa condução do caso. O objetivo deste estudo foi relatar um caso clínico de uma paciente com cardiomiopatia de Takotsubo após pneumonia e internação hospitalar. A importância do tema é ressaltada pela raridade do tema e pelo seu subdiagnóstico. Mulher,77 anos com história de disfagia de transferência evoluindo após 10 dias com tosse produtiva de coloração amarelada. Diagnosticada e internada com pneumonia broncoaspirativa e iniciada antibioticoterapia. No sétimo dia de internação evoluiu com precordialgia associada a dispneia. História mórbida de acidente vascular cerebral (AVC) isquêmico há 4 anos com sequela de hemiplegia esquerda e crises convulsivas. O eletrocardiograma (ECG) demonstrou supradesnivelamento do segmento ST emparede ântero-septal. À cinecoronariografia ausência de lesões obstrutivas significativas e à ventriculografia e ecocardiograma discinesia de ventrículo esquerdo com abalonamento ântero-infero-apical. No caso descrito os fatores desencadeantes ficaram claros sendo o estresse físico pela pneumonia e emocional pela internação hospitalar. O quadro clínico apresentado pela paciente associado a cinecoronariografia, ecocardiografia e eletrocardiografia e o padrão de reversibilidade da disfunção cardíaca nos remetem ao diagnóstico de Cardiomiopatia de Takotsubo.

Also called the Broken Heart Syndrome, Takotsubo syndrome is a cardiovascular disease similar to acute myocardial infarction clinical, however, with normal coronary arteries on coronary angiography. Is usually associated with events of emotional or physical stress. The knowledge of pathology for diagnosis and good management of the case is necessary. The aim of this study was to report a clinical case of a patient with Takotsubo cardiomyopathy after pneumonia and hospitalization. The importance of this issue is underscored by the rarity of the subject and its underdiagnosis. Female, 77 years with a history of dysphagia transfer evolving after 10 days with cough productive of yellowish. She was diagnosed with aspiration pneumonia and hospitalized with antibiotic therapy initiated. On the seventh day of hospitalization developed chest pain associated with dyspnea. Morbid history of ischemic stroke 4 years ago sequel with left hemiplegia and seizures. The ECG showed ST segment elevation in the anteroseptal wall. In the absence of significant obstructive coronary angiography and ventriculography lesions and echocardiographic left ventricular dyskinesia with anterior infero-apical bulging. In the case described, the triggering factors were the physical and emotional stress by the pneumonia and hospitalization. The clinical presentation by the patient associated with coronary angiography, echocardiography and electrocardiography and standard reversibility of cardiac dysfunction refer us to diagnosis of the Takotsubo Cardiomyopathy.

Postoperative Takotsubo cardiomyopathy.

Takotsubo cardiomyopathy also known as transient apical ballooning syndrome or stress induced reversible cardiomyopathy is an increasingly reported syndrome generally characterized by transient systolic dysfunction of the apical and/or mid segment of the left ventricle. It is frequently precipitated by severe stress and clinically mimics an acute ST‑elevation myocardial infarction, with angiographically normal coronary arteries. A high index of suspicion is needed to diagnose this syndrome. We describe a patient who developed Takotsubo cardiomyopathy in the post‑operative period following vaginal hysterectomy.

Cardiomiopatia de Takotsubo: Relato de caso e revisão de literatura / Takotsubo cardiomyopathy: Case report and review of the literature

Cardiomiopatia de Takotsubo (CMT) é uma doença caracterizada por disfunção ventricular esquerda aguda em resposta a estresse físico ou emocional. Relata-se o caso de uma mulher, 82 anos, que foi hospitalizada com queixa de dor torácica e dispneia. A paciente apresentou alterações eletrocardiográficas, elevação das enzimas cardíacas, alterações de movimento da parede do ventrículo esquerdo (VE), mimetizando síndrome coronariana aguda (SCA), todavia as coronárias estavam angiograficamente normais. Apresentou como complicações da CMT insuficiência cardíaca esquerda com edema agudo de pulmão, disfunção valvar mitral e formação de trombo em ápice de VE. A função ventricular esquerda foi completamente recuperada em três semanas.

Takotsubo cardiomyopathy (TCM) is a disease characterized by acute left ventricular dysfunction in response to physical or emotional stress. This report addresses the case of an 82-year-old woman hospitalized for chest pain and dyspnea. The patient presented electrocardiographic alterations, elevated heart enzymes and left ventricular (LV) wall motion changes, mimicking acute coronary syndrome (ACS), but with angiographically normal coronary arteries. The complications resulting from TCM were: left side heart failure with acute pulmonary edema, mitral valve disorder and thrombus formation in the LV apex. The left ventricular function was recovered completely in three weeks.